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A functional polymorphism in the promoter of ERK5 gene interacts with tobacco smoking to increase the risk of lung cancer in Chinese populations.

Mutagenesis - 1 Sept 2013

Qiu Fuman, Yang Lei, Fang Wenxiang, Li Yinyan, Yang Rongrong, Yang Xiaorong, Deng Jieqiong, Huang Binfang, Xie Chenli, Zhou Yifeng, Lu Jiachun

Abstract excerpt

Mitogen/extracellular signal-regulated kinase-5 (MEK5)/extracellular signal-regulated protein kinase-5 (ERK5) pathway plays a pro-oncogenic role in tumourigenesis by anticell apoptosis, promoting cell proliferation and differentiation in response to extracellular stimuli. As overexpressed MEK5/ERK5 is involved in the development of lung cancer, we hypothesised that the single nucleotide polymorphisms (SNPs) in...

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PMID: 23804708
DOI: 10.1093/mutage/get033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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