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Article

Mitogen/extracellular signal-regulated kinase kinase-5 promoter region polymorphisms affect the risk of sporadic colorectal cancer in a southern Chinese population.

DNA and cell biology - 1 Mar 2012

Diao Dechang, Wang Lei, Zhang Jun-Xiao, Chen Dianke, Liu Huanliang, Wei Yisheng, Lu Jiachun, Peng Junsheng, Wang Jianping

Abstract excerpt

Mitogen/extracellular signal-regulated kinase kinase-5 (MEK5), which belongs to a network of mitogen-activated protein kinase pathways, play a pivotal role in carcinogenesis. The purpose of this study was to investigate whether variants in the MEK5 gene promoter were involved in susceptivity of individuals to sporadic colorectal cancer (CRC). In the present hospital-based case-control study of 737 patients with...

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Identifiers

PMID: 21861603
DOI: 10.1089/dna.2011.1232
PMCID: PMC3300074

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