Article
Genetic variants of JNK and p38α pathways and risk of non-small cell lung cancer in an Eastern Chinese population.
International journal of cancer - 15 Feb 2017
Jia Ming, Zhu Meiling, Zhou Fei, Wang Mengyun, Sun Menghong, Yang Yajun, Wang Xiaofeng, Wang Jiucun, Jin Li, Xiang Jiaqing, Zhang Yawei, Chang Jianhua, Wei Qingyi
Abstract excerpt
The JNK and p38α pathways play an important role in carcinogenesis. Therefore, we hypothesize that single nucleotide polymorphisms (SNPs) of genes involved in these pathways are associated with risk of lung cancer. We first selected and genotyped 11 independent SNPs of the JNK and p38α pathway-related genes in a discovery set of 1,002 non-small cell lung cancer (NSCLC) cases and 1,025 cancer-free controls of...
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