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Article

Latent HIV-1 can be reactivated by cellular superinfection in a Tat-dependent manner, which can lead to the emergence of multidrug-resistant recombinant viruses.

Journal of virology - 1 Sept 2013

Donahue Daniel A, Bastarache Sophie M, Sloan Richard D, Wainberg Mark A

Abstract excerpt

The HIV-1 latent reservoir represents an important source of genetic diversity that could contribute to viral evolution and multidrug resistance following latent virus reactivation. This could occur by superinfection of a latently infected cell. We asked whether latent viruses might be reactivated when their host cells are superinfected, and if so, whether they could contribute to the generation of recombinant...

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Share to Drug Resistance, Multiple, Viral
Share to Genes, tat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Reassortant Viruses

Share to Receptors, CXCR4

Share to Superinfection

Share to tat Gene Products, Human Immunodeficiency Virus

Share to Virus Activation

Share to Virus Latency

Source

Open in PubMed Open full text

Identifiers

PMID: 23804632
DOI: 10.1128/JVI.01165-13
PMCID: PMC3754111

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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