Current Status of Latency Reversing Agents Facing the Heterogeneity of HIV-1 Cellular and Tissue Reservoirs

Abstract excerpt

One of the most explored therapeutic approach aiming at eradicating the HIV-1 reservoirs is the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells (“shock” phase), while maintaining ART in order to prevent spreading of the infection by the neosynthesized virus. This kind of strategy would allow the “kill” phase during which latently-infected cells would then die from viral...

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