Article
Development of an Attenuated Tat Protein as a Highly-effective Agent to Specifically Activate HIV-1 Latency.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Sept 2016
Geng Guannan, Liu Bingfeng, Chen Cancan, Wu Kang, Liu Jun, Zhang Yijun, Pan Ting, Li Jun, Yin Yue, Zhang Junsong, Huang Feng, Yu Fei, Chen Jingliang, Ma Xiancai, Zhou Jie, Kuang Ersheng, Liu Chao, Cai Weiping, Zhang Hui
Abstract excerpt
Although combined antiretroviral therapy (cART) successfully decreases plasma viremia to undetectable levels, the complete eradication of human immunodeficiency virus type 1 (HIV-1) remains impractical because of the existence of a viral reservoir, mainly in resting memory CD4(+) T cells. Various cytokines, protein kinase C activators, and histone deacetylase inhibitors (HDACi) have been used as latency-reversing...
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