Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Viral Protein Tat Can Inhibit the Establishment of HIV-1 Latency

12 Jan 2012

Abstract excerpt

The establishment of HIV-1 latency can result from limiting levels of transcription initiation or elongation factors, restrictive chromatin modifications, transcriptional interference, and insufficient Tat activity. Since the viral protein Tat can counteract many of these factors, we hypothesized that the presence of exogenous Tat during infection might inhibit the establishment of latency. This was explored...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to HIV Research and Treatment
Share to Virology and Viral Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22238306
DOI: 10.1128/jvi.06648-11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Viral Protein Tat Can Inhibit the Establishment of HIV-1 LatencyPMID 22238306Read ↗

Variation in HIV-1 Tat activity is a key determinant in the establishment of latent infectionSemantic proximity Read ↗

HIV-1 transcription and latency: an updateSemantic proximity Read ↗

Cellular and molecular mechanisms involved in the establishment of HIV-1 latencySemantic proximity Read ↗

The Molecular Basis for Human Immunodeficiency Virus LatencySemantic proximity Read ↗

Lost in Transcription: Molecular Mechanisms that Control HIV LatencySemantic proximity Read ↗

Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts.Semantic proximity Read ↗

Key Players in HIV-1 Transcriptional Regulation: Targets for a Functional CureSemantic proximity Read ↗

HIV latency: experimental systems and molecular modelsSemantic proximity Read ↗

Role of HIV-1 Tat Protein Interactions with Host Receptors in HIV Infection and PathogenesisSemantic proximity Read ↗

Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?Semantic proximity Read ↗

The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation.Semantic proximity Read ↗

Determinants of the Establishment of Human Immunodeficiency Virus Type 1 LatencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.