Article

Promoter evolution in HIV-1C establishes latent reservoirs highly resistant to reversal

2025-08-02

Abstract excerpt

Latent viral reservoirs remain a major barrier to curing HIV-1, with the long-terminal repeat (LTR) and Tat playing crucial roles in regulating viral transcription. Subtype-specific transcription factor binding site (TFBS) variations within the LTR significantly influence latency and reservoir stability. In earlier work, we identified HIV-1C LTR variants with duplicated TFBS motifs, including NF-κB, AP1, RBEIII, a...

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Literature Corpus work: 09946154-eb21-5b3a-8d26-631684e5254d
DOI: 10.1101/2025.08.02.668273

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