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Are centenarians genetically predisposed to lower disease risk?

Age (Dordrecht, Netherlands) - 1 Oct 2012

Ruiz Jonatan R, Fiuza-Luces Carmen, Buxens Amaya, Cano-Nieto Amalia, Gómez-Gallego Félix, Santiago Catalina, Rodríguez-Romo Gabriel, Garatachea Nuria, Lao José I, Morán María, Lucia Alejandro

Abstract excerpt

Our study purpose was to compare a disease-related polygenic profile that combined a total of 62 genetic variants among (i) people reaching exceptional longevity, i.e., centenarians (n = 54, 100-108 years, 48 women) and (ii) ethnically matched healthy controls (n = 87, 19-43 years, 47 women). We computed a 'global' genotype score (GS) for 62 genetic variants (mutations/polymorphisms) related to cardiometabolic...

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Identifiers

PMID: 21894447
DOI: 10.1007/s11357-011-9296-3
PMCID: PMC3448993

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GSTT1
GSTM1

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