Article
Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jun 2014
Ohka Fumiharu, Ito Maki, Ranjit Melissa, Senga Takeshi, Motomura Ayako, Motomura Kazuya, Saito Kaori, Kato Keiko, Kato Yukinari, Wakabayashi Toshihiko, Soga Tomoyoshi, Natsume Atsushi
Abstract excerpt
Isocitrate dehydrogenase 1 (IDH1), which localizes to the cytosol and peroxisomes, catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG) and in parallel converts NADP(+) to NADPH. IDH1 mutations are frequently detected in grades 2-4 gliomas and in acute myeloid leukemias (AML). Mutations of IDH1 have been identified at codon 132, with arginine being replaced with histidine in most cases....
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