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Article

An IDH1 mutation inhibits growth of glioma cells via GSH depletion and ROS generation.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Jun 2014

Shi Jinlong, Zuo Hao, Ni Lanchun, Xia Liang, Zhao Longxiang, Gong Mingjie, Nie Dekang, Gong Peipei, Cui Daming, Shi Wei, Chen Jian

Abstract excerpt

The isocitrate dehydrogenase 1 (IDH1) gene mutation occurs frequently in glioma. While some studies have demonstrated that IDH1 mutations are associated with prolonged survival, the mechanism remains unclear. In this study, we found that growth was significantly inhibited in glioma cells overexpr...

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Source

Identifiers

PMID: 24362902
DOI: 10.1007/s10072-013-1607-2

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-24362902-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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An IDH1 mutation inhibits growth of glioma cells via GSH depletion and ROS generation.PMID 24362902Read ↗

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IDH1 overexpression induced chemotherapy resistance and IDH1 mutation enhanced chemotherapy sensitivity in Glioma cells in vitro and in vivo.Semantic proximity Read ↗

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