Article
The positive association of obesity variants with adulthood adiposity strengthens over an 80-year period: a gene-by-birth year interaction.
Human heredity - 1 Jan 2013
Demerath Ellen W, Choh Audrey C, Johnson William, Curran Joanne E, Lee Miryoung, Bellis Claire, Dyer Thomas D, Czerwinski Stefan A, Blangero John, Towne Bradford
Abstract excerpt
OBJECTIVE: To test the hypothesis that the statistical effect of obesity-related genetic variants on adulthood adiposity traits depends on birth year. METHODS: The study sample included 907 related, non-Hispanic White participants in the Fels Longitudinal Study, born between 1901 and 1986, and aged 25-64.99 years (474 females; 433 males) at the time of measurement. All had both genotype data from which a genetic...
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