Article
Determining the stability of genome-wide factors in BMI between ages 40 to 69 years.
PLoS genetics - 1 Aug 2022
Gillespie Nathan A, Gentry Amanda Elswick, Kirkpatrick Robert M, Reynolds Chandra A, Mathur Ravi, Kendler Kenneth S, Maes Hermine H, Webb Bradley T, Peterson Roseann E
Abstract excerpt
Genome-wide association studies (GWAS) have successfully identified common variants associated with BMI. However, the stability of aggregate genetic variation influencing BMI from midlife and beyond is unknown. By analysing 165,717 men and 193,073 women from the UKBiobank, we performed BMI GWAS on six independent five-year age intervals between 40 and 72 years. We then applied genomic structural equation modeling...
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