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Article

Distinct genetic profiles influence body mass index between infancy and adolescence.

Nature communications - 19 Feb 2026

Wang Geng, McEwan Samuel, Zeng Jian, Haile-Mariam Mekonnen, Yengo Loic, Goddard Michael E, Kemper Kathryn E, Warrington Nicole M

Abstract excerpt

Body mass index (BMI) changes throughout life with age-varying genetic contributions. We use a random regression model to investigate the genetic contribution to BMI trajectories from ages one to 18 years in 6,291 ALSPAC participants with 65,930 repeated BMI measurements. Here we show the estimated SNP-based heritability of BMI at 9.5 years is 28.4% (SE = 4.8%), and 23.8% (SE = 4.2%) for rate of change in BMI...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41714618
DOI: 10.1038/s41467-026-69310-6
PMCID: PMC12920650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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