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Article

The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin.

The Journal of biological chemistry - 17 Dec 1999

Thomas J W, Cooley M A, Broome J M, Salgia R, Griffin J D, Lombardo C R, Schaller M D

Abstract excerpt

Focal adhesion kinase (FAK) and paxillin are focal adhesion-associated, phosphotyrosine-containing proteins that physically interact. A previous study has demonstrated that paxillin contains two binding sites for FAK. We have further characterized these two binding sites and have demonstrated that the binding affinity of the carboxyl-terminal domain of FAK is the same for each of the two binding sites. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10593973
DOI: 10.1074/jbc.274.51.36684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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