Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion.

doi:10.1158/0008-5472.CAN-07-1998

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Article

Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion.

Cancer research - 1 Jan 2008

Jagadeeswaran Ramasamy, Surawska Hanna, Krishnaswamy Soundararajan, Janamanchi Varalakshmi, Mackinnon A Craig, Seiwert Tanguy Y, Loganathan Sivakumar, Kanteti Rajani, Reichman Trevor, Nallasura Vidya, Schwartz Stuart, Faoro Leonardo, Wang Yi-Ching, Girard Luc, Tretiakova Maria S, Ahmed Salman, Zumba Osvaldo, Soulii Lioubov, Bindokas Vytas P, Szeto Livia L, Gordon Gavin J, Bueno Raphael, Sugarbaker David, Lingen Mark W, Sattler Martin, Krausz Thomas, Vigneswaran Wickii, Natarajan Viswanathan, Minna John, Vokes Everett E, Ferguson Mark K, Husain Aliya N, Salgia Ravi

Abstract excerpt

Lung cancer is characterized by abnormal cell growth and invasion, and the actin cytoskeleton plays a major role in these processes. The focal adhesion protein paxillin is a target of a number of oncogenes involved in key signal transduction and important in cell motility and migration. In lung c...

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PMID: 18172305
DOI: 10.1158/0008-5472.CAN-07-1998
PMCID: PMC2767335

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EGFR
MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18172305-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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