Article
Absence of paxillin gene mutation in lung cancer and other common solid cancers.
Tumori - 1 Jan 2000
Kim Min Sung, Yoo Nam Jin, Lee Sug Hyung
Abstract excerpt
AIMS AND BACKGROUND: Mounting evidence indicates that deregulated cell adhesion is involved in the mechanisms of cancer pathogenesis. A recent study showed that the paxillin gene (PXN) encoding a focal adhesion protein was somatically mutated in lung cancers. The aim of this study was to confirm the presence of PXN mutations in lung cancers as well as in other common solid cancers. METHODS: We analyzed somatic...
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