Article

Profilin 2 regulates pyruvate kinase M2 nuclear translocation and potentiates tumor angiogenesis in non-small cell lung cancer

2023-04-24

Abstract excerpt

Profilin 2 (PFN2) is an actin-binding protein important for cancer initiation and progression. However, the function and precise role of PFN2 in non-small cell lung cancer (NSCLC) remain unclear. Here, we assessed the expression levels of PFN2 in tissue from patients with NSCLC; identified binding partners using mass spectrometry, co-immunoprecipitations, and molecular modeling; and studied the angiogenic-promotin...

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Literature Corpus work: 10d77f2e-0d39-5ed9-b7b6-1a48534ef118
DOI: 10.21203/rs.3.rs-2834608/v1

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