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Article

Recombinant filaggrin is internalized and processed to correct filaggrin deficiency.

The Journal of investigative dermatology - 1 Feb 2014

Stout Thomas E, McFarland Trevor, Mitchell John C, Appukuttan Binoy, Timothy Stout J

Abstract excerpt

This study was designed to engineer a functional filaggrin (FLG) monomer linked to a cell-penetrating peptide (RMR) and to test the ability of this peptide to penetrate epidermal tissue as a therapeutic strategy for genetically determined atopic dermatitis (AD). A single repeat of the murine filaggrin gene (Flg) was covalently linked to a RMR motif and cloned into a bacterial expression system for protein...

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Source

Identifiers

PMID: 23792461
DOI: 10.1038/jid.2013.284

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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