Article
Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice.
The Journal of allergy and clinical immunology - 1 Jun 2012
Kawasaki Hiroshi, Nagao Keisuke, Kubo Akiharu, Hata Tsuyoshi, Shimizu Atsushi, Mizuno Hideaki, Yamada Taketo, Amagai Masayuki
Abstract excerpt
BACKGROUND: Loss-of-function mutations in filaggrin are major predisposing factors for atopic dermatitis. Although various reports suggest a critical role for filaggrin in stratum corneum (SC) barrier formation, the lack of filaggrin-null (Flg(-/-)) mice has hampered detailed in vivo analysis of filaggrin's functions. OBJECTIVE: We sought to generate Flg(-/-) mice and to assess the effect of filaggrin loss on SC...
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