Article
DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway.
Cell reports - 27 Jun 2013
Wan Guohui, Zhang Xinna, Langley Robert R, Liu Yunhua, Hu Xiaoxiao, Han Cecil, Peng Guang, Ellis Lee M, Jones Stephen N, Lu Xiongbin
Abstract excerpt
Expression of microRNAs (miRNAs) involves transcription of miRNA genes and maturation of the primary transcripts. Recent studies have shown that posttranscriptional processing of primary and precursor miRNAs is induced after DNA damage through regulatory RNA-binding proteins in the Drosha and Dicer complexes, such as DDX5 and KSRP. However, little is known about the regulation of nuclear export of pre-miRNAs in...
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