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Article

Modulation of microRNA processing by p53.

Nature - 23 Jul 2009

Suzuki Hiroshi I, Yamagata Kaoru, Sugimoto Koichi, Iwamoto Takashi, Kato Shigeaki, Miyazono Kohei

Abstract excerpt

MicroRNAs (miRNAs) have emerged as key post-transcriptional regulators of gene expression, involved in diverse physiological and pathological processes. Although miRNAs can function as both tumour suppressors and oncogenes in tumour development, a widespread downregulation of miRNAs is commonly observed in human cancers and promotes cellular transformation and tumorigenesis. This indicates an inherent...

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PMID: 19626115
DOI: 10.1038/nature08199

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DDX5

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