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Article

ATM is down-regulated by N-Myc–regulated microRNA-421

4 Jan 2010

Abstract excerpt

Ataxia-telangiectasia mutated (ATM) is a high molecular weight protein serine/threonine kinase that plays a central role in the maintenance of genomic integrity by activating cell cycle checkpoints and promoting repair of DNA double-strand breaks. Little is known about the regulatory mechanisms for ATM expression itself. MicroRNAs are naturally existing regulators that modulate gene expression in a...

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PMID: 20080624
DOI: 10.1073/pnas.0907763107

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ATM is down-regulated by N-Myc–regulated microRNA-421PMID 20080624Read ↗

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