Article
A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells.
Cancer cell - 19 Oct 2010
Melo Sonia A, Moutinho Catia, Ropero Santiago, Calin George A, Rossi Simona, Spizzo Riccardo, Fernandez Agustin F, Davalos Veronica, Villanueva Alberto, Montoya Guillermo, Yamamoto Hiroyuki, Schwartz Simo, Esteller Manel
Abstract excerpt
The global impairment of mature microRNAs (miRNAs) is emerging as a common feature of human tumors. One interesting scenario is that defects in the nuclear export of precursor miRNAs (pre-miRNAs) might occur in transformed cells. Exportin 5 (XPO5) mediates pre-miRNA nuclear export and herein we demonstrate the presence of XPO5-inactivating mutations in a subset of human tumors with microsatellite instability. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.