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Article

Protein tyrosine phosphatases in health and disease.

The FEBS journal - 1 Jan 2013

Hendriks Wiljan J A J, Elson Ari, Harroch Sheila, Pulido Rafael, Stoker Andrew, den Hertog Jeroen

Abstract excerpt

Protein tyrosine phosphatases (PTPs) represent a super-family of enzymes that play essential roles in normal development and physiology. In this review, we will discuss the PTPs that have a causative role in hereditary diseases in humans. In addition, recent progress in the development and analysis of animal models expressing mutant PTPs will be presented. The impact of PTP signaling on health and disease will be...

Topics

Animals
Bone Development
Central Nervous System Diseases
Disease Models, Animal
Genetic Predisposition to Disease
Humans
Mutation
Protein Tyrosine Phosphatases
Signal Transduction
Synapses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22938156
DOI: 10.1111/febs.12000

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