Article
High trans-ethnic replicability of GWAS results implies common causal variants.
PLoS genetics - 1 Jun 2013
Marigorta Urko M, Navarro Arcadi
Abstract excerpt
Genome-wide association studies (GWAS) have detected many disease associations. However, the reported variants tend to explain small fractions of risk, and there are doubts about issues such as the portability of findings over different ethnic groups or the relative roles of rare versus common variants in the genetic architecture of complex disease. Studying the degree of sharing of disease-associated variants...
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