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Article

Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study.

PLoS biology - 1 Sept 2013

Carlson Christopher S, Matise Tara C, North Kari E, Haiman Christopher A, Fesinmeyer Megan D, Buyske Steven, Schumacher Fredrick R, Peters Ulrike, Franceschini Nora, Ritchie Marylyn D, Duggan David J, Spencer Kylee L, Dumitrescu Logan, Eaton Charles B, Thomas Fridtjof, Young Alicia, Carty Cara, Heiss Gerardo, Le Marchand Loic, Crawford Dana C, Hindorff Lucia A, Kooperberg Charles L

Abstract excerpt

The vast majority of genome-wide association study (GWAS) findings reported to date are from populations with European Ancestry (EA), and it is not yet clear how broadly the genetic associations described will generalize to populations of diverse ancestry. The Population Architecture Using Genomics and Epidemiology (PAGE) study is a consortium of multi-ancestry, population-based studies formed with the objective...

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PMID: 24068893
DOI: 10.1371/journal.pbio.1001661
PMCID: PMC3775722

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