An opposite-direction modulation of the COMT Val158Met polymorphism on the clinical response to intrathecal morphine and triptans.

doi:10.1016/j.jpain.2013.04.006

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Article

An opposite-direction modulation of the COMT Val158Met polymorphism on the clinical response to intrathecal morphine and triptans.

The journal of pain - 1 Oct 2013

Cargnin Sarah, Magnani Francesco, Viana Michele, Tassorelli Cristina, Mittino Daniela, Cantello Roberto, Sances Grazia, Nappi Giuseppe, Canonico Pier Luigi, Genazzani Armando A, Raffaeli William, Terrazzino Salvatore

Abstract excerpt

UNLABELLED: Genetic variation in the COMT gene is thought to have clinical implications for pain perception and pain treatment. In the present study, we first evaluated the association between COMT rs4680 and the analgesic response to intrathecal morphine in patients with chronic low back pain to...

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Identifiers

PMID: 23773341
DOI: 10.1016/j.jpain.2013.04.006

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23773341-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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