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Article

COMT Genotype and Efficacy of Propranolol for TMD Pain: A Randomized Trial.

Journal of dental research - 1 Feb 2021

Slade G D, Fillingim R B, Ohrbach R, Hadgraft H, Willis J, Arbes S J, Tchivileva I E

Abstract excerpt

Propranolol is a nonselective β-adrenergic receptor antagonist that is efficacious in reducing facial pain. There is evidence that its analgesic efficacy might be modified by variants of the catechol-O-methyltransferase (COMT) gene. We tested the hypothesis in a subset of 143 non-Hispanic Whites from a randomized controlled trial of patients with painful temporomandibular disorder (TMD). Patients were genotyped...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33030089
DOI: 10.1177/0022034520962733
PMCID: PMC8163522

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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