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Article

COMT Val158Met Affects the Analgesic Response to Acupuncture Among Cancer Survivors With Chronic Pain.

The journal of pain - 1 Sept 2023

Yang Mingxiao, Baser Raymond E, Khanin Raya, Autuori Isidora, Li Qing S, Panageas Katherine S, Orlow Irene, Mao Jun J

Abstract excerpt

Catechol-O-methyltransferase (COMT) is the major enzyme involved in the catabolism of dopamine, a neurotransmitter in the brain's reward system. The common COMT polymorphism Val158Met (rs4680 G>A) modulates pain response to opioids through a reward-motivated mechanism; however, its role in nonpharmacological pain medicine has not been clinically characterized. We genotyped 325 participants from a randomized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37187218
DOI: 10.1016/j.jpain.2023.05.005
PMCID: PMC11321469

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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COMT Val158Met Affects the Analgesic Response to Acupuncture Among Cancer Survivors With Chronic Pain.PMID 37187218Read ↗

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