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Article

Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis.

Pharmacogenetics and genomics - 1 Sept 2012

Tammimäki Anne, Männistö Pekka T

Abstract excerpt

In human studies, low COMT (catechol-O-methyltransferase) activity has been associated with increased sensitivity to acute clinical preoperative or postoperative pain. We explored the association between the COMT genotype and three chronic pain conditions: migrainous headache, fibromyalgia, or chronic widespread pain and chronic musculoskeletal pain. Furthermore, we evaluated whether COMT genotype affects the...

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Source

Identifiers

PMID: 22722321
DOI: 10.1097/FPC.0b013e3283560c46

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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