Article
The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after lumbar disc herniation.
European journal of pain (London, England) - 1 Aug 2012
Jacobsen L M, Schistad E I, Storesund A, Pedersen L M, Rygh L J, Røe C, Gjerstad J
Abstract excerpt
BACKGROUND: The COMT enzyme metabolizes catecholamines and thus modulates adrenergic, noradrenergic and dopaminergic signaling. A functional polymorphism in the gene encoding this enzyme, i.e. the COMT Val158Met SNP that reduces enzyme activity, has previously been linked to pain sensitivity. METHODS: We examined if the COMT Val158Met SNP could contribute to discogenic subacute low back pain and sciatica by...
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