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Article

Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the BioBIM rs4818 and rs4680 polymorphisms study.

The journal of headache and pain - 1 Jan 2015

De Marchis Maria Laura, Barbanti Piero, Palmirotta Raffaele, Egeo Gabriella, Aurilia Cinzia, Fofi Luisa, Piroso Serena, Ialongo Cristiano, Della-Morte David, D'Andrea Giovanni, Ferroni Patrizia, Guadagni Fiorella

Abstract excerpt

BACKGROUND: The study of COMT gene polymorphisms in migraine could be of particular interest since impaired catecholaminergic neurotransmission, namely chronic dopaminergic and noradrenergic hypofunction, is a peculiar migraine trait. In this study, for the first time, we focused on the role of COMT rs4818 genetic variant, the polymorphism most strongly affecting COMT activity, in migraine. This study was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25929431
DOI: 10.1186/s10194-015-0520-x
PMCID: PMC4441644

Genes

COMT

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