The polymorphism Val158Met in the COMT gene: disrupted dopamine system in fibromyalgia patients?

doi:10.1097/j.pain.0000000000003313

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The polymorphism Val158Met in the COMT gene: disrupted dopamine system in fibromyalgia patients?

Pain - 1 Dec 2024

Gerra Maria Carla, Dallabona Cristina, Manfredini Matteo, Giordano Rocco, Capriotti Camilla, González-Villar Alberto, Triñanes Yolanda, Arendt-Nielsen Lars, Carrillo-de-la-Peña Maria Teresa

Abstract excerpt

ABSTRACT: The single-nucleotide polymorphism (SNP) rs4680 in the catechol-O-methyltransferase gene ( COMT ) is a missense variant (Val158Met) associated with altered activity of the COMT enzyme and suggested as a predictive feature for developing some chronic pain conditions. However, there are controversial results on its role in fibromyalgia (FM). Here, the SNP Val158Met was analyzed in 294 FM patients (without...

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PMID: 38916531
DOI: 10.1097/j.pain.0000000000003313
PMCID: PMC11562751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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