Article
Genetic architecture of circulating lipid levels.
European journal of human genetics : EJHG - 1 Jul 2011
Demirkan Ayşe, Amin Najaf, Isaacs Aaron, Jarvelin Marjo-Riitta, Whitfield John B, Wichmann Heinz-Erich, Kyvik Kirsten O H M, Rudan Igor, Gieger Christian, Hicks Andrew A, Johansson Åsa, Hottenga Jouke-Jan, Smith Johannes J, Wild Sarah H, Pedersen Nancy L, Willemsen Gonneke, Mangino Massimo, Hayward Caroline, Uitterlinden André G, Hofman Albert, Witteman Jacqueline, Montgomery Grant W, Pietiläinen Kirsi H, Rantanen Taina, Kaprio Jaakko, Döring Angela, Pramstaller Peter P, Gyllensten Ulf, de Geus Eco J C, Penninx Brenda W, Wilson James F, Rivadeneria Fernando, Magnusson Patrik K E, Boomsma Dorret I, Spector Tim, Campbell Harry, Hoehne Birgit, Martin Nicholas G, Oostra Ben A, McCarthy Mark, Peltonen-Palotie Leena, Aulchenko Yurii, Visscher Peter M, Ripatti Samuli, Janssens A Cecile J W, van Duijn Cornelia M
Abstract excerpt
Serum concentrations of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and total cholesterol (TC) are important heritable risk factors for cardiovascular disease. Although genome-wide association studies (GWASs) of circulating lipid levels have identified numerous loci, a substantial portion of the heritability of these traits remains unexplained....
Topics
- Female
- Genome-Wide Association Study
- Humans
- Lipid Metabolism
- Lipids
- Male