Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis.

doi:10.1161/CIRCGENETICS.112.963140

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Article

Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis.

Circulation. Cardiovascular genetics - 1 Feb 2013

Shah Sonia, Casas Juan-Pablo, Drenos Fotios, Whittaker John, Deanfield John, Swerdlow Daniel I, Holmes Michael V, Kivimaki Mika, Langenberg Claudia, Wareham Nick, Gertow Karl, Sennblad Bengt, Strawbridge Rona J, Baldassarre Damiano, Veglia Fabrizio, Tremoli Elena, Gigante Bruna, de Faire Ulf, Kumari Meena, Talmud Philippa J, Hamsten Anders, Humphries Steve E, Hingorani Aroon D

Abstract excerpt

BACKGROUND: Carotid intima-media thickness (CIMT), a subclinical measure of atherosclerosis, is associated with risk of coronary heart disease events. Statins reduce progression of CIMT and coronary heart disease risk in proportion to the reduction in low-density lipoprotein cholesterol. However, interventions targeting triglycerides (TGs) or high-density lipoprotein cholesterol (HDL-C) have produced inconsistent...

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PMID: 23275344
DOI: 10.1161/CIRCGENETICS.112.963140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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