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Article

Multiple associated variants increase the heritability explained for plasma lipids and coronary artery disease.

Circulation. Cardiovascular genetics - 1 Oct 2014

Tada Hayato, Won Hong-Hee, Melander Olle, Yang Jian, Peloso Gina M, Kathiresan Sekar

Abstract excerpt

BACKGROUND: Plasma lipid levels as well as coronary artery disease (CAD) have been shown to be highly heritable with estimates ranging from 40% to 60%. However, top variants detected by large-scale genome-wide association studies explain only a fraction of the total variance in plasma lipid phenotypes and CAD. METHODS AND RESULTS: We performed a conditional and joint association analysis using summary-level...

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Source

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Identifiers

PMID: 25170055
DOI: 10.1161/CIRCGENETICS.113.000420
PMCID: PMC4341828

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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