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Article

Phosphatidylinositol-4,5-bisphosphate regulates NMDA receptor activity through alpha-actinin.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 May 2007

Michailidis Ioannis E, Helton Thomas D, Petrou Vasileios I, Mirshahi Tooraj, Ehlers Michael D, Logothetis Diomedes E

Abstract excerpt

Phosphatidylinositol-4,5-bisphosphate (PIP2) has been shown to regulate many ion channels, transporters, and other signaling proteins, but it is not known whether it also regulates neurotransmitter-gated channels. The NMDA receptors (NMDARs) are gated by glutamate and serve as a critical control point in synaptic function. Here we demonstrate that PIP2 supports NMDAR activity. In Xenopus oocytes, overexpression...

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Identifiers

PMID: 17507574
DOI: 10.1523/JNEUROSCI.4378-06.2007
PMCID: PMC6672336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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