Article
Mutation of neuron-specific chromatin remodeling subunit BAF53b: rescue of plasticity and memory by manipulating actin remodeling.
Learning & memory (Cold Spring Harbor, N.Y.) - 1 May 2017
Vogel Ciernia Annie, Kramár Enikö A, Matheos Dina P, Havekes Robbert, Hemstedt Thekla J, Magnan Christophe N, Sakata Keith, Tran Ashley, Azzawi Soraya, Lopez Alberto, Dang Richard, Wang Weisheng, Trieu Brian, Tong Joyce, Barrett Ruth M, Post Rebecca J, Baldi Pierre, Abel Ted, Lynch Gary, Wood Marcelo A
Abstract excerpt
Recent human exome-sequencing studies have implicated polymorphic Brg1-associated factor (BAF) complexes (mammalian SWI/SNF chromatin remodeling complexes) in several intellectual disabilities and cognitive disorders, including autism. However, it remains unclear how mutations in BAF complexes result in impaired cognitive function. Post-mitotic neurons express a neuron-specific assembly, nBAF, characterized by...
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