Article
Genetic resistance to liver fibrosis on A/J mouse chromosome 17.
Alcoholism, clinical and experimental research - 1 Oct 2013
DeSantis David A, Lee Peter, Doerner Stephanie K, Ko Chih-Wei, Kawasoe Jean H, Hill-Baskin Annie E, Ernest Sheila R, Bhargava Prerna, Hur Kyu Yeon, Cresci Gail A, Pritchard Michele T, Lee Chih-Hao, Nagy Laura E, Nadeau Joseph H, Croniger Colleen M
Abstract excerpt
BACKGROUND: Because the histological and biochemical progression of liver disease is similar in alcoholic steatohepatitis (ASH) and nonalcoholic steatohepatitis (NASH), we hypothesized that the genetic susceptibility to these liver diseases would be similar. To identify potential candidate genes that regulate the development of liver fibrosis, we studied a chromosome substitution strain (CSS-17) that contains...
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