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The M16 Mouse: An Outbred Animal Model of Early Onset Polygenic Obesity and Diabesity

1 Sept 2004

Abstract excerpt

OBJECTIVE: To characterize the phenotypic consequences of long-term selective breeding for rapid weight gain, with an emphasis on obesity and obesity-induced diabetes (diabesity). RESEARCH METHODS AND PROCEDURES: M16 is the result of long-term selection for 3- to 6-week weight gain from an ICR base population. Experiment 1 characterized males from both lines for body weights (3, 6, and 8 weeks), feed (4 to 8...

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PMID: 15483204
DOI: 10.1038/oby.2004.176

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