Article
The relative timing of mutations in a breast cancer genome.
PloS one - 1 Jan 2013
Newman Scott, Howarth Karen D, Greenman Chris D, Bignell Graham R, Tavaré Simon, Edwards Paul A W
Abstract excerpt
Many tumors have highly rearranged genomes, but a major unknown is the relative importance and timing of genome rearrangements compared to sequence-level mutation. Chromosome instability might arise early, be a late event contributing little to cancer development, or happen as a single catastroph...
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