Article

In BRCA1 and BRCA2 breast cancers, chromosome breaks occur near herpes tumor virus sequences

2021-04-20

Abstract excerpt

Inherited mutations in BRCA1 and BRCA2 genes increase risks for breast, ovarian, and other cancers. Both genes encode proteins for accurately repairing chromosome breaks. If mutations inactivate this function, broken chromosome fragments get lost or reattach indiscriminately. These mistakes are characteristic of hereditary breast cancer. We tested the hypothesis that mistakes in reattaching broken chromosomes pref...

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Literature Corpus work: 2433ad4c-dbaf-5a8d-9c9f-18fb2501b406
DOI: 10.1101/2021.04.19.440499

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