Article
Genome evolution during progression to breast cancer.
Genome research - 1 Jul 2013
Newburger Daniel E, Kashef-Haghighi Dorna, Weng Ziming, Salari Raheleh, Sweeney Robert T, Brunner Alayne L, Zhu Shirley X, Guo Xiangqian, Varma Sushama, Troxell Megan L, West Robert B, Batzoglou Serafim, Sidow Arend
Abstract excerpt
Cancer evolution involves cycles of genomic damage, epigenetic deregulation, and increased cellular proliferation that eventually culminate in the carcinoma phenotype. Early neoplasias, which are often found concurrently with carcinomas and are histologically distinguishable from normal breast tissue, are less advanced in phenotype than carcinomas and are thought to represent precursor stages. To elucidate their...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.