Article
Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers.
Science translational medicine - 12 Jun 2013
Potter Rachel, Patterson Bruce W, Elbert Donald L, Ovod Vitaliy, Kasten Tom, Sigurdson Wendy, Mawuenyega Kwasi, Blazey Tyler, Goate Alison, Chott Robert, Yarasheski Kevin E, Holtzman David M, Morris John C, Benzinger Tammie L S, Bateman Randall J
Abstract excerpt
Alzheimer's disease (AD) is hypothesized to be caused by an overproduction or reduced clearance of amyloid-β (Aβ) peptide. Autosomal dominant AD (ADAD) caused by mutations in the presenilin (PSEN) gene have been postulated to result from increased production of Aβ42 compared to Aβ40 in the central nervous system (CNS). This has been demonstrated in rodent models of ADAD but not in human mutation carriers. We used...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.