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Article

Aβ43 levels determine the onset of pathological amyloid deposition.

The Journal of biological chemistry - 1 Jul 2023

Tambini Marc D, Yin Tao, Yesiltepe Metin, Breuillaud Lionel, Zehntner Simone P, d'Abramo Cristina, Giliberto Luca, D'Adamio Luciano

Abstract excerpt

About 2% of Alzheimer's disease (AD) cases have early onset (FAD) and are caused by mutations in either Presenilins (PSEN1/2) or amyloid-β precursor protein (APP). PSEN1/2 catalyze production of Aβ peptides of different length from APP. Aβ peptides are the major components of amyloid plaques, a pathological lesion that characterizes AD. Analysis of mechanisms by which PSEN1/2 and APP mutations affect Aβ peptide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37257821
DOI: 10.1016/j.jbc.2023.104868
PMCID: PMC10404620

Genes

APP
PSEN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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