Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees.

doi:10.1523/JNEUROSCI.0730-07.2007

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Article

Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Jun 2007

Klunk William E, Price Julie C, Mathis Chester A, Tsopelas Nicholas D, Lopresti Brian J, Ziolko Scott K, Bi Wenzhu, Hoge Jessica A, Cohen Ann D, Ikonomovic Milos D, Saxton Judith A, Snitz Beth E, Pollen Daniel A, Moonis Majaz, Lippa Carol F, Swearer Joan M, Johnson Keith A, Rentz Dorene M, Fischman Alan J, Aizenstein Howard J, DeKosky Steven T

Abstract excerpt

The amyloid cascade hypothesis suggests that the aggregation and deposition of amyloid-beta protein is an initiating event in Alzheimer's disease (AD). Using amyloid imaging technology, such as the positron emission tomography (PET) agent Pittsburgh compound-B (PiB), it is possible to explore the natural history of preclinical amyloid deposition in people at high risk for AD. With this goal in mind, asymptomatic...

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Identifiers

PMID: 17553989
DOI: 10.1523/JNEUROSCI.0730-07.2007
PMCID: PMC3265970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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