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Article

Switched Aβ43 generation in familial Alzheimer's disease with presenilin 1 mutation.

Translational psychiatry - 3 Nov 2021

Kakuda Nobuto, Takami Mako, Okochi Masayasu, Kasuga Kensaku, Ihara Yasuo, Ikeuchi Takeshi

Abstract excerpt

Presenilin (PS) with a genetic mutation generates abundant β-amyloid protein (Aβ) 43. Senile plaques are formed by Aβ43 in the cerebral parenchyma together with Aβ42 at middle ages. These brains cause the early onset of Alzheimer's disease (AD), which is known as familial Alzheimer's disease (FAD). Based on the stepwise processing model of Aβ generation by γ-secretase, we reassessed the levels of Aβs in the...

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Identifiers

PMID: 34728605
DOI: 10.1038/s41398-021-01684-1
PMCID: PMC8564532

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