Article
High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types.
Archives of neurology - 1 Dec 2009
Villemagne Victor L, Ataka Suzuka, Mizuno Toshiki, Brooks William S, Wada Yasuhiro, Kondo Masaki, Jones Gareth, Watanabe Yasuyoshi, Mulligan Rachel, Nakagawa Masanori, Miki Takami, Shimada Hiroyuki, O'Keefe Graeme J, Masters Colin L, Mori Hiroshi, Rowe Christopher C
Abstract excerpt
BACKGROUND: Supported by compelling genetic data regarding early-onset familial Alzheimer disease (AD), the amyloid beta-peptide (Abeta)-centric theory holds that Abeta is involved in the pathogenesis of sporadic AD. Mutations in the amyloid precursor protein (APP), presenilin 1 (PSEN1), and pres...
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