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Article

Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception.

Nature - 25 Mar 2010

Kang Kyeongjin, Pulver Stefan R, Panzano Vincent C, Chang Elaine C, Griffith Leslie C, Theobald Douglas L, Garrity Paul A

Abstract excerpt

Chemical nociception, the detection of tissue-damaging chemicals, is important for animal survival and causes human pain and inflammation, but its evolutionary origins are largely unknown. Reactive electrophiles are a class of noxious compounds humans find pungent and irritating, such as allyl isothiocyanate (in wasabi) and acrolein (in cigarette smoke). Diverse animals, from insects to humans, find reactive...

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Identifiers

PMID: 20237474
DOI: 10.1038/nature08848
PMCID: PMC2845738

Genes

TRPA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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